12 Night Cruise sailing from Pittsburg to St Louis aboard American Queen.

Upper Mississippi Cruises:
Early explorers and native tribes left their legacy behind in town names here: Joliet. Red Wing. Dubuque. Rolling farmland stretches out to the horizon; barges are measured in acres; man-made lakes and locks channel the river's flow. What to do on a river day? Grab your binoculars and study a pair of American bald eagles. Wave to the motorboat captains locking through the dam beside you. Study red in ten different shades of fall foliage. Tap into the sense of wonder that caused early pioneers to call the heartland home.

Destinations handpicked to pique the interest of nature lovers, history buffs and culture enthusiasts let you delve into beauty and adventure on an epic scale. After all, this is America's Heartland, envisioned by Washington and Jefferson, celebrated by Mark Twain and stitched into the very fabric of a nation. From Chippewa country in the north to the confluence of the Missouri near St. Louis and Ohio Rivers at Cairo, the Upper Mississippi flows through the pages of U.S. history.

Lewis & Clark / Route 66
Join us on this intriguing itinerary as we travel from Pittsburgh, PA to St. Louis, MO. This journey will explore portions of the historical route of Lewis & Clark, as well as the much celebrated and legendary US Highway - Route 66.

Day 1: Pittsburgh, PA
Departure: 6:00 p.m.
Enjoy the sights and sounds of Pittsburgh. This afternoon, you will board the American Queen to begin your voyage. As your ship leaves Pittsburgh, envision the adventures that lie ahead. The Welcome Aboard Dinner gets your journey off to a festive start.

Day 2: Wheeling, WV
Arrival: 8:00 a.m. - Departure: 1:00 p.m.
Included Tour: Start the tour with a fantastic visit to trendy shops, eateries, entertainment and more at the Centre Market. Venture out and discover the story of West Virginia's relationship to the Civil War at the West Virginia Independence Hall.

Then, take a gander at the delightful decorated living quarters of the grand Victorian Eckhart House. Final option for the tour: a stop at the Capitol Theatre, host to a variety of Broadway shows and theater productions.

Day 3: Marietta, OH
Arrival: 8:00 a.m. - Departure: 1:00 p.m.
Included Tour: Begin this journey with a walking tour of Front Street. Then explore the opulent Gothic Revival architecture and art collection of The Castle.

The Mound Cemetery is home to the largest number of American Revolutionary War officers buried in one location. Later, check out museums around the area. The Campus Martius Museum showcases the history of America's migration west, and the Ohio River Museum lets you discover the golden age of the steamboat and learn about the ecology of the Ohio river system.

Make a shopping, shopping and more shopping stop at Downtown Shopping Center. The Historic Harmar Village has plenty to offer, from eateries to boutiques, museums and more.

Day 4: Point Pleasant, WV
Arrival: 8:00 a.m. - Departure: 1:00 p.m.
Included Tour: Start with a walking tour of Point Pleasant Riverfront Park, where floodwall murals depict scenes of local history, the most popular being the Battle of Point Pleasant. Next to the list is the four-acre Tu-Endie-Wei State Park, which commemorates the October 1774 Battle of Point Pleasant. Visit the Mansion House, erected in 1796 as a tavern and now preserved as a museum with displays of period antiques and heirlooms.

The Point Pleasant River Museum is dedicated to preserving the heritage and way of life on the Ohio and Great Kanawha Rivers. Enjoy some shopping time downtown at the Twin River Area.

Day 5: Portsmouth, OH
Arrival: 8:00 a.m. - Departure: 1:00 p.m.
Portsmouth's roots began in the 1790s when the small town of Alexandria was founded just west of where Portsmouth is today. Alexandria was flooded numerous times by the Ohio River and the Scioto River. In 1803, Henry Massie spotted a place to move the town away from the flood plains. He began to plot the new city by distributing the land and mapping the streets. Portsmouth was founded in 1803 and was established as a city in 1815. Alexandria soon disappeared. Portsmouth quickly grew around an industrial base with the completion of the Ohio and Erie Canal, and the construction of the N&W rail yards and the B&O junction.

Day 6: Cincinnati, OH
Arrival: 8:00 a.m. - Departure: 1:00 p.m.
Included Tour: Board your hop-on hop-off Steamcoach for a narrated tour of Cincinnati's many attractions. Enjoy the storied history of the Cincinnati Reds at the Reds Hall of Fame and Museum for a small admission fee, a place where the story of Reds baseball comes alive each day. Established in 1958, the Reds Hall of Fame is the largest in all of baseball. Your next stop is the National Underground Railroad Freedom Center, a Smithsonian Institution affiliate, honoring courageous ideas and African- American history. Entry fees are additional.

As your journey continues, you will stop at Fountain Square, the heart of Cincinnati, Ohio. Located at the corner of Fifth and Vine Streets, Fountain Square is a public space where Cincinnatians gather, celebrate and connect as a city. You will then Steamcoach to scenic Eden Park and enjoy the included attractions. The Cincinnati Art Museum houses an unparalleled collection of more than 60,000 works spanning 6,000 years and hosts several national and international traveling exhibitions each year. Enjoy some green space at The Krohn Conservatory, where a variety of floral plants are displayed in the Palm House and Desert House, including bonsai and orchid displays. You will also enjoy the Eden Park Observation Point, where you will view landmarks including Hinkle Magnolia Garden, a picturesque gazebo, Mirror Lake, Bettman Fountain and a spectacular view of the city.

At the final stop on your hop-on hop-off experience, you will enjoy, for additional admission, the Newport Aquarium which showcases thousands of animals from around the world in one million gallons of water. You will be amazed at all of the fun and interactive activities, like touching a shark or meeting a penguin. You may also want to take advantage of the many shops and restaurants in this very vibrant area of the city.

Day 7: Louisville, KY
Arrival: 8:00 a.m. - Departure: 5:00 p.m.
From its frontier founding at the time of the American Revolution, to the heyday of Steamboat transport in the early 19th century, through the city's importance as a Union base during the Civil War, Louisville has always balanced a sense of history with an ability to re-invent itself as the city of originals.

Day 8: Steamboating
Settle into a rocking chair and just let the scenery glide by. Or join in the fun of our numerous onboard activities. Your full day of leisurely steamboating on the river sets the tone for an unforgettable vacation.

Day 9: Henderson, KY
Arrival: 8:00 a.m. - Departure: 1:00 p.m.
Enjoy a leisurely stroll through Henderson, the hometown of famed naturalist John James Audubon. Reminders of his famous bird paintings are around every corner. See if you can find all eight of the town's bronze bird statues. With a growing population, thriving downtown, historic turn-of-the-century mansions overlooking the river, and a recently renovated riverfront, Henderson exhibits the best qualities of an historic southern river town.

Day 10: Paducah, KY
Arrival: 8:00 a.m. - Departure: 5:00 p.m.
Known as the city of art, rhythm and rivers, Paducah boasts a lively Lowertown Arts District, the renowned River Heritage Museum, a Save America's Treasures project, and tours via foot, trolley or horse-drawn carriage reveal its charm. OR Elegant displays at the Museum of the American Quilter's Society highlight the vigorous rebirth of quiltmaking. It's just one of the colorful attractions in a lovely city of 19th century architecture, specialty shops and one-of-a-kind eateries.

Day 11: Cape Girardeau, MO
Arrival: 10:00 a.m. - Departure: 5:00 p.m.
Included Tour: Start the tour with visits to several different houses and museums that cover much of Cape Girardeau's history. Riverfront Murals is a concrete and granite cobblestone amphitheater that provides seating for a scenic look of the Mississippi River.

Red House Interpretive Center shows an exhibit reflecting the lives of those who called the Old Cape Girardeau District home. The Old St. Vincent's Church displays Renaissance architecture in English Gothic Revival style. Next is the Glenn House, a museum that features architecture, furnishings, clothing and more from the Victorian era.

Check out spectacular vistas of historic landmark houses and views from the Mississippi River at the River Campus of Southeast Missouri State University, Old Bridge Overlook and Park, and the Crisp Museum. Then, you'll make one last stop at the Cape River Heritage Museum, located inside an old fire station built in 1908, which houses river-related artifacts and historical items.

Day 12: Chester, IL
Arrival: 8:00 a.m. - Departure: 5:00 p.m.
Samuel Smith built the first home in Chester, established a ferry system, and began the construction of a mill in 1829. He is said to be the town's founder. It was his wife Jane Thomas, a native of Chester, England, who gave Chester its name as a tribute to her home town. The Chester area includes a number of state parks and historic sites. The Fort Kaskaskia State Historic Site has a beautiful overlook of the Mississippi River. Down the hill from the park is the Pierre Menard Home, an unusually fine example of French Creole-style architecture, which was built around 1815 and was the home of the first lieutenant governor of Illinois. Across the river from the fort is Kaskaskia Island, the only part of Illinois west of the current channel of the Mississippi River. The island was the site of the first state capital of Illinois. A historic church founded by French explorer Pere Jacques Marquette still holds weekly mass on the island. The Liberty Bell of the West, older than the Liberty Bell in Philadelphia, is located near the church on the island and was a gift from King Louis XV of France.

Day 13: Disembark in St. Louis, MO
After breakfast, keep an eye out for St. Louis' Gateway Arch. This iconic landmark is a symbol of America's frontier journey. Bid your fellow travelers adieu as you make your way home.